Apparatuses, systems and methods for perforating and aspirating inner ear

Aksit, Aykut, Kysar, Jeffrey W, Lalwani, Anil K, Arteaga, Daniel N

Journal / Patent

Contrast Enhancement of Cochlea after Direct Microneedle Intracochlear Injection of Gadodiamide through the Round Window Membrane with Minimal Dosage

Zhou, Chaoqun, Feng, Sharon J, Leong, Stephen, Breil, Eug\'enie, Voruz, Franccois, Valentini, Chris, Hammer, Daniella R, Aksit, Aykut, Olson, Elizabeth S, Guo, Jia, others

Academic Radiology

Microneedle-mediated intracochlear injection safely achieves higher perilymphatic dexamethasone concentration than intratympanic delivery in guinea pig

Voruz, Francois, Feng, Sharon J, Breil, Eugenie, Yu, Michelle, Hammer, Daniella R, Aksit, Aykut, Zandkarimi, Fereshteh, Olson, Elizabeth S, Kysar, Jeffrey W, Lalwani, Anil K

Drug Delivery and Translational Research

Novel dual-lumen microneedle delivers adeno-associated viral vectors in the guinea pig inner ear via the round window membrane

Hammer, Daniella R, Voruz, Franccois, Aksit, Aykut, Breil, Eug\'enie, Rousset, Francis, Senn, Pascal, Ilmj\"arv, Sten, Olson, Elizabeth S, Lalwani, Anil K, Kysar, Jeffrey W

Biomedical Microdevices

Physiologic Effects of Microneedle-Mediated Intracochlear Dexamethasone Injection in the Guinea Pig

Feng, Sharon J, Leong, Stephen, Aksit, Aykut, H\'ebert, Daniella, Olson, Elizabeth S, Kysar, Jeffrey W, Lalwani, Anil K

The Laryngoscope

Microneedle-mediated delivery of siRNA via liposomal-based transfection for inner ear gene therapy

Feng, Sharon J, Voruz, Franccois, Leong, Stephen, Hammer, Daniella R, Breil, Eug\'enie, Aksit, Aykut, Yu, Michelle, Chiriboga, Lauren, Olson, Elizabeth S, Kysar, Jeffrey W, others

Otology \& Neurotology

Microneedle Mediated Intracochlear Delivery

Lalwani, Anil K, Kysar, Jeffrey W, Aksit, Aykut

Journal / Patent

Anatomic, physiologic, and proteomic consequences of repeated microneedle-mediated perforations of the round window membrane

Leong, Stephen, Aksit, Aykut, Szeto, Betsy, Feng, Sharon J, Ji, Xiang, Soni, Rajesh K, Olson, Elizabeth S, Kysar, Jeffrey W, Lalwani, Anil K

Hearing Research

Microneedles facilitate small-volume intracochlear delivery without physiologic injury in guinea pigs

Leong, Stephen, Feng, Sharon J, Aksit, Aykut, Olson, Elizabeth S, Kysar, Jeffrey W, Lalwani, Anil K

Otology \& Neurotology

Microneedles to deliver therapeutic agent across membranes

Aksit, Aykut, Lalwani, Anil K, Kysar, Jeffrey W, West, Alan

Journal / Patent

Inner ear diagnostics and drug delivery via microneedles

Leong, Stephen, Aksit, Aykut, Feng, Sharon J, Kysar, Jeffrey W, Lalwani, Anil K

Journal of Clinical Medicine

Pyrolyzed ultrasharp glassy carbon microneedles

Zhou, Chaoqun, Aksit, Aykut, Szeto, Betsy, Li, Richard L, Lalwani, Anil K, Kysar, Jeffrey W

Advanced engineering materials

Drug delivery device for the inner ear: ultra-sharp fully metallic microneedles

Aksit, Aykut, Rastogi, Shruti, Nadal, Maria L, Parker, Amber M, Lalwani, Anil K, West, Alan C, Kysar, Jeffrey W

Drug delivery and translational research

Novel 3D-printed hollow microneedles facilitate safe, reliable, and informative sampling of perilymph from guinea pigs

Szeto, Betsy, Aksit, Aykut, Valentini, Chris, Yu, Michelle, Werth, Emily G, Goeta, Shahar, Tang, Chuanning, Brown, Lewis M, Olson, Elizabeth S, Kysar, Jeffrey W, others

Hearing research

Simulation assisted design for microneedle manufacturing: Computational modeling of two-photon templated electrodeposition

Aksit, Aykut, Lalwani, Anil K, Kysar, Jeffrey W, West, Alan C

Journal of manufacturing processes

Impact of systemic versus intratympanic dexamethasone administration on the perilymph proteome

Szeto, Betsy, Valentini, Chris, Aksit, Aykut, Werth, Emily G, Goeta, Shahar, Brown, Lewis M, Olson, Elizabeth S, Kysar, Jeffrey W, Lalwani, Anil K

Journal of proteome research

3D-printed microneedles create precise perforations in human round window membrane in situ

Chiang, Harry, Yu, Michelle, Aksit, Aykut, Wang, Wenbin, Stern-Shavit, Sagit, Kysar, Jeffrey W, Lalwani, Anil K

Otology \& Neurotology

Anatomical and functional consequences of microneedle perforation of round window membrane

Yu, Michelle, Arteaga, Daniel N, Aksit, Aykut, Chiang, Harry, Olson, Elizabeth S, Kysar, Jeffrey W, Lalwani, Anil K

Otology \& Neurotology

Small molecule delivery across a perforated artificial membrane by thermoreversible hydrogel poloxamer 407

Santimetaneedol, A, Wang, Z, Arteaga, DN, Aksit, A, Prevoteau, C, Yu, M, Chiang, H, Fafalis, D, Lalwani, AK, Kysar, JW

Colloids and Surfaces B: Biointerfaces

In-vitro perforation of the round window membrane via direct 3-D printed microneedles

Aksit, Aykut, Arteaga, Daniel N, Arriaga, Miguel, Wang, Xun, Watanabe, Hirobumi, Kasza, Karen E, Lalwani, Anil K, Kysar, Jeffrey W

Biomedical microdevices